Regression of left ventricular hypertrophy in two-kidney, one clip Goldblatt hypertension.

Regression of left ventricular hypertrophy in two-kidney, one clip Goldblatt hypertension.

The effect of regression of left ventricular hypertrophy (LVH) on ventricular performance was studied in two-kidney, one clip Goldblatt hypertensive rats (2K1C) treated with methyldopa or by unclipping. Sham operations were performed in a total of 21 rats; 12 and nine were studied after 4 and 6 weeks, respectively. Hypertension was induced in 38 additional rats. Of these, 11 were studied at 4 w...

Dietary potassium and the development of hypertension in two-kidney, one clip Goldblatt hypertensive rats.

Importance of the renal nerves in established two-kidney, one clip Goldblatt hypertension.

Increased sympathetic nervous system activity has been demonstrated in established twokidney, one clip hypertension in the rat. To determine the importance of the renal nerves in this model of hypertension, renal denervation of the clipped kidney (n = IS), renal denotation of the nondlpped kidney (n = 14), sham operation (n = 20), or undlpping (n = 12) was carried out 6 weeks after the onset of...

Increased angiotensin-converting enzyme activity of aorta in two-kidney, one-clip Goldblatt hypertension in rats.

There is increasing evidence that conversion of angiotensin I into angiotensin I1 can occur in the renal vasculature of humans [l l , and in the vascular beds of the hind limb of the dog 121. In previous experiments the specific angiotensionconverting enzyme in rat aorta [31 has been demonstrated. More recently, Mizuno et al. [41 have studied the subcellular localization of the enzyme activity ...

Exchangeable sodium in Goldblatt one-kidney one-clip hypertension in the rat.

Exchangeable sodium (NaE), plasma active renin concentration and blood pressure were measured in rats with a sole remaining kidney before and after the development of hypertension induced by clipping of the single renal artery and again after unclipping. Control observations were made in sham-clipped and sham-unclipped uninephrectomized rats. Renal artery clipping caused hypertension and expans...